The activities of the liver and serum lactate dehydrogenase were studied when cholestasis was induced by common bile duct (CBD) ligation in rats and chronic ethanol intoxication developed, or cholestasis following acute ethanol intoxication for
manifestation of the biochemical background of alcohol intoxication in hepatobiliary disease.
There was no significant change in the liver and serum lactate dehydrogenase activities of rats treated with both acute or chronic ethanol intoxition.
The liver lactate dehygrogenase activity showed a significant decrease at the 2nd, 3rd, 7th and 14th days following the ligation in both the groups with the ligation following the chronical ethanol intoxication and the groups only with CBD
ligation.
The acute intoxication with ethanol which was done after 14 days of the CBD ligation, the rats liver lactate dehydrogenase activities decreased considerably and the same was seen in the group with the 14th day following the CBD ligation.
The groups that received CBD ligation after being chronically intoxicated with ethanol showed a marked increase at the 1st, 2nd, 3 rd, 7th and 14th days following the ligation in the sera lactate dehydrogenase activities. However, the activities
showed
a far higher degree tan groups of the CBD ligation. For the groups of acute intoxication with ethanol done after 14 days of the CBD ligation, the sera lactate dehydrogenase activities increased markadly, but the activities showed a higher degree
than
the group with the 14th day following the CBD ligation.
According to the above results, when the acute and chronic ethanol intoxication with cholestasis occurred, the sera lactate dehydrogenase activities are higher than in cholestasis because of increased liver cell damage, which causes the enzyme to
leak
into the blood in great quantity. Accordingly, these results will be the data supprorting alcoholic drink is enzymologically harmful in hepatobiliary disease.
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